Hypoxic pre-conditioning increases the infiltration of endothelial cells into scaffolds for dermal regeneration pre-seeded with mesenchymal stem cells


Fernando A. Fierro, Adam J. O’Neal , Julie R. Beegle, Myra N. Chávez, Thomas R. Peavy, Roslyn R. Isseroff , and José T. Egaña

Front Cell Dev Biol. 2015; 3: 68. Published online 2015 Oct 30

Here we describe human bone marrow-derived MSC seeded in Integra matrices, a common type of scaffold for dermal regeneration (SDR). We show and measured the distribution of MSC within the SDR, where cells clearly establish physical interactions with the scaffold, exhibiting constant metabolic activity for at least 15 days.

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