Human Umbilical Cord Blood Cells Induce Neuroprotective Change in Gene Expression Profile in Neurons After Ischemia Through Activation of Akt Pathway


Shahaduzzaman, M. D.; Mehta, Vijay; Golden, Jason E.; Rowe, Derrick D.; Green, Suzanne; Tadinada, Ramya; Foran, Elspeth A.; Sanberg, Paul R.; Pennypacker, Keith R.; Willing, Alison E.

Cell Transplantation, Volume 24, Number 4, 2015, pp. 721-735(15)

Human umbilical cord blood (HUCB) cell therapies have shown promising results in reducing brain infarct volume and most importantly in improving neurobehavioral function in rat permanent middle cerebral artery occlusion, a model of stroke. In this study, we examined the gene expression profile in neurons subjected to oxygen-glucose deprivation (OGD) with or without HUCB treatment and identified signaling pathways (Akt/MAPK) important in eliciting HUCB-mediated neuroprotective responses.

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