Human Mesenchymal Stromal/Stem Cell-Mediated Bone Marrow Organization

Yasuo Miura , Tatsuo Ichinohe, Taira Maekawa

Japanese Journal of Transfusion and Cell Therapy Vol. 61 (2015) No. 5 p. 489-490

Mesenchymal stromalstem cells (MSCs) in bone marrow differentiate into cellular components of the hematopoietic cell niche, including osteogenic cells. A human MSC transplantation into mice (xenotransplantation model) is one of the best available in vivo models to recapitulate MSC-mediated bone and bone marrow organization.

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