HIV-1 is Restricted Prior to Integration in Primary Cord-Derived Human CD34+ Cells


Daniel O. Griffin and Stephen Goff

JVI Accepted Manuscript Posted Online 20 May 2015

Certain cells have the ability to block retroviral infection at specific stages of the viral cycle by the activities of well-characterized factors and transcriptional silencing machinery. Infection of murine stem cells (MSCs) by the murine leukemia viruses (MLVs) is profoundly blocked post-integration by transcriptional silencing.

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