Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures

Seung-Tae Lee, Marcus O. Muench, Marina E. Fomin, Jianqiao Xiao, Mi Zhou, Adam de Smith, Jose I. Martın-Subero, Simon Heath, E. Andres Houseman, Ritu Roy, Margaret Wrensch, John Wiencke, Catherine Metayer, and Joseph L. Wiemels

Nucleic Acids Research, 2015, published online February 17, 2015

We investigated DNA methylomes of pediatric Bcell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and highdefinition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compartments and demethylation of large intercompartmental backbones.

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