Central memory CD4+ T cells are preferential targets of double infection by HIV-1

Aiman A. Haqqani , Samantha L. Marek, Jagadish Kumar, Miles Davenport, Heng Wang, and John C. Tilton

Virology Journal 2015 12:184 Published: 11 November 2015

Template switching between two distinct HIV-1 RNA genomes during reverse transcription gives rise to recombinant viruses that greatly expand the genetic diversity of HIV-1 and have adverse implications for drug resistance, immune escape, and vaccine design. Virions with two distinct genomes are produced exclusively from cells infected with two or more viruses, or ‘doubly infected’ cells.

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