Stromal & Mesenchymal Cells

Human Mesenchymal Stromal/Stem Cell-Mediated Bone Marrow Organization

Yasuo Miura , Tatsuo Ichinohe, Taira Maekawa

Japanese Journal of Transfusion and Cell Therapy Vol. 61 (2015) No. 5 p. 489-490

Mesenchymal stromalstem cells (MSCs) in bone marrow differentiate into cellular components of the hematopoietic cell niche, including osteogenic cells. A human MSC transplantation into mice (xenotransplantation model) is one of the best available in vivo models to recapitulate MSC-mediated bone and bone marrow organization.

Hypoxic pre-conditioning increases the infiltration of endothelial cells into scaffolds for dermal regeneration pre-seeded with mesenchymal stem cells

Fernando A. Fierro, Adam J. O’Neal , Julie R. Beegle, Myra N. Chávez, Thomas R. Peavy, Roslyn R. Isseroff , and José T. Egaña

Front Cell Dev Biol. 2015; 3: 68. Published online 2015 Oct 30

Here we describe human bone marrow-derived MSC seeded in Integra matrices, a common type of scaffold for dermal regeneration (SDR). We show and measured the distribution of MSC within the SDR, where cells clearly establish physical interactions with the scaffold, exhibiting constant metabolic activity for at least 15 days.