Human Mesenchymal Stromal/Stem Cell-Mediated Bone Marrow Organization
Yasuo Miura , Tatsuo Ichinohe, Taira Maekawa
Japanese Journal of Transfusion and Cell Therapy Vol. 61 (2015) No. 5 p. 489-490
Mesenchymal stromalstem cells (MSCs) in bone marrow differentiate into cellular components of the hematopoietic cell niche, including osteogenic cells. A human MSC transplantation into mice (xenotransplantation model) is one of the best available in vivo models to recapitulate MSC-mediated bone and bone marrow organization.
Hypoxic pre-conditioning increases the infiltration of endothelial cells into scaffolds for dermal regeneration pre-seeded with mesenchymal stem cells
Fernando A. Fierro, Adam J. O’Neal , Julie R. Beegle, Myra N. Chávez, Thomas R. Peavy, Roslyn R. Isseroff , and José T. Egaña
Front Cell Dev Biol. 2015; 3: 68. Published online 2015 Oct 30
Here we describe human bone marrow-derived MSC seeded in Integra matrices, a common type of scaffold for dermal regeneration (SDR). We show and measured the distribution of MSC within the SDR, where cells clearly establish physical interactions with the scaffold, exhibiting constant metabolic activity for at least 15 days.
View by Topic
CELL TYPE
TISSUE TYPE