Cord Blood

Cord Blood

Human Umbilical Cord Blood Cells Induce Neuroprotective Change in Gene Expression Profile in Neurons After Ischemia Through Activation of Akt Pathway

Shahaduzzaman, M. D.; Mehta, Vijay; Golden, Jason E.; Rowe, Derrick D.; Green, Suzanne; Tadinada, Ramya; Foran, Elspeth A.; Sanberg, Paul R.; Pennypacker, Keith R.; Willing, Alison E.

Cell Transplantation, Volume 24, Number 4, 2015, pp. 721-735(15)

Human umbilical cord blood (HUCB) cell therapies have shown promising results in reducing brain infarct volume and most importantly in improving neurobehavioral function in rat permanent middle cerebral artery occlusion, a model of stroke. In this study, we examined the gene expression profile in neurons subjected to oxygen-glucose deprivation (OGD) with or without HUCB treatment and identified signaling pathways (Akt/MAPK) important in eliciting HUCB-mediated neuroprotective responses.

HIV-1 is Restricted Prior to Integration in Primary Cord-Derived Human CD34+ Cells

Daniel O. Griffin and Stephen Goff

JVI Accepted Manuscript Posted Online 20 May 2015

Certain cells have the ability to block retroviral infection at specific stages of the viral cycle by the activities of well-characterized factors and transcriptional silencing machinery. Infection of murine stem cells (MSCs) by the murine leukemia viruses (MLVs) is profoundly blocked post-integration by transcriptional silencing.

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