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Whole Bone Marrow Aspirate

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Catalog # : ABM001-0

Bone Marrow (BM) contains hematopoietic stem/progenitor cells, which have the potential to self-renew, proliferate, and differentiate into multi-lineage blood cells. Multipotent, non-hematopoietic stem cells, such as mesenchymal stem cells, can be isolated from human BM as well. These non-hematopoietic, mesenchymal stem cells are capable of both self-renewal and differentiation into bone, cartilage, muscle, tendons, and fat. BM is drawn into a 60cc syringe containing heparin (80 U/mL of BM) from the posterior iliac crest, 25 mL/site, from a maximum of four sites. 
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Catalog #FormatProduct nameSizePriceQuantity 
ABM001-1Fresh Whole Bone Marrow Aspirate3 mL
$276.00
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ABM001Fresh Whole Bone Marrow Aspirate10 mL
$461.00
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ABM002Fresh Whole Bone Marrow Aspirate25 mL
$1,000.00
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ABM003Fresh Whole Bone Marrow Aspirate50 mL
$1,946.00
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ABM004Fresh Whole Bone Marrow Aspirate100 mL
$3,508.00
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$276.00
Overview

Additional Information

Bone Marrow (BM) contains hematopoietic stem/progenitor cells, which have the potential to self-renew, proliferate, and differentiate into multi-lineage blood cells. Multipotent, non-hematopoietic stem cells, such as mesenchymal stem cells, can be isolated from human BM as well. These non-hematopoietic, mesenchymal stem cells are capable of both self-renewal and differentiation into bone, cartilage, muscle, tendons, and fat. BM is drawn into a 60cc syringe containing heparin (80 U/mL of BM) from the posterior iliac crest, 25 mL/site, from a maximum of four sites. 

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Donor Criteria

Age18-65 years old
Weight>= 130 lbs
Screened before donationHIV (HIV 1 & 2 Ab)
HBV (Surface Antigen HbsAg)
HCV (HCVAb)
Donation FrequencyMinimum 10 weeks between donations
Donors with any of the following will be excluded from donatingPregnancy
History of heart, lung, liver, or kidney disease
History of asthma
Blood and bleeding disorders including sickle cell disease
Neurologic disorders
Autoimmune disorders
Cancer
Diabetes
Other CriteriaMust be in general good health
Must have accessible hips
Complete Blood Count lab test must meet protocol specs
Required to sign procedure-specific consent form

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Applications/Publications

Applications

  • Proof of concept studies for allogenic immunotherapy and gene therapy products
  • Hematopoetic Stem Cell expansion
  • Colony-forming assays
  • Toxicology studies

To Study

  • Progenitor cell differentiation
  • Growth factor studies

Related Bioservices

  • ISHAGE
  • CFU

Publications

Bone regeneration in calvarial defects in a rat model by implantation of human bone marrow-derived mesenchymal stromal cell spheroids

Hideyuki Suenaga, Katsuko S. Furukawa, Yukako Suzuki, Tsuyoshi Takato, Takashi Ushida
Source: Journal of Materials Science: Materials in Medicine November 2015

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Overexpression of the Toll-Like Receptor (TLR) Signaling Adaptor MYD88, but Lack of Genetic Mutation, in Myelodysplastic Syndromes

Dimicoli S, Wei Y, Bueso-Ramos C, Yang H, DiNardo C, et al.
Source: PLoS ONE 8(8): e71120. doi:10.1371/journal.pone.0071120 Published August 15, 2013

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Enhanced Osteogenesis of Human Mesenchymal Stem Cells by Periodic Heat Shock in Self-Assembling Peptide Hydrogel

Jing Chen, MS, et al.
Source: TISSUE ENGINEERING: Part A Volume 19, Numbers 5 and 6, 2013

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A subset of IL-17+ mesenchymal stem cells possesses anti-Candida albicans effect

Ruili Yang, et al.
Source: Cell Research (2013) 23:107-121. 25 December 2012

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An optimized algorithm for detecting and annotating regional differential methylation

Sheng Li, et al.
Source: BMC Bioinformatics 2013, 14(Suppl 5):S10

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Amphiregulin-EGFR Signaling Mediates the Migration of Bone Marrow Mesenchymal Progenitors toward PTHStimulated Osteoblasts and Osteocytes

Ji Zhu, et al.
Source: PLoS ONE 7(12): e50099 December 31, 2012

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Base-Pair Resolution DNA Methylation Sequencing Reveals Profoundly Divergent Epigenetic Landscapes in Acute Myeloid Leukemia

Altuna Akalin, et al.
Source: PLoS Genet 8(6): e1002781. doi:10.1371/journal.pgen.1002781 June 21, 2012

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Increased Potency of Cardiac Stem Cells Compared with Bone Marrow Mesenchymal Stem Cells in Cardiac Repair

BEHZAD N. OSKOUEI, et al.
Source: Stem Cells Trans Med February 2012 vol. 1 no. 2 116-124

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Genz-644282, a Novel Non-Camptothecin Topoisomerase I Inhibitor for Cancer Treatment

Leslie S. Kurtzberg, et al.
Source: Clin Cancer Res May 1, 2011 17; 2777

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The Minimal Instrumentation Requirements for Hoechst Side Population Analysis: Stem Cell Analysis on Low-Cost Flow Cytometry Platforms

RAQUEL CABANA, et al.
Source: STEMCELLS 2006;24:2573–2581

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Prospective isolation of human clonogenic common myeloid progenitors

Markus G. Manz, et al.
Source: 11872–11877  PNAS  September 3, 2002  vol. 99  no. 18

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Inhibitory Role for Dual Specificity Phosphatase VHR in T Cell Antigen Receptor and CD28-induced Erk and Jnk Activation

Andres Alonso, et al.
Source: THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 276, No. 7, Issue of February 16, pp. 4766–4771, 2001

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Immunomodulatory properties of stem cells from human exfoliated deciduous teeth

Takayoshi Yamaza, et al.
Source: Yamaza et al. Stem Cell Research & Therapy 2010, 1:5

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Human Adult Marrow Cells Support Prolonged Expansion of Human Embryonic Stem Cells in Culture

LINZHAO CHENG, et al.
Source: STEM CELLS 2003;21:131-142

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HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs

Christoph C Carter, et al.
Source: nature medicine: doi:10.1038/nm.2109 March 19, 2009

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Generation of Antitumor Invariant Natural KillerT Cell Lines in MultipleMyeloma and Promotion ofTheir Functions via Lenalidomide: A Strategy for Immunotherapy

Weihua Song, et al.
Source: Clin Cancer Res 2008;6955 14(21) November 1, 2008

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Defective osteogenesis of the stromal stem cells predisposes CD18-null mice to osteoporosis

Yasuo Miura, et al.
Source: www.pnas.orgcgidoi10.1073pnas.0409397102

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CD34CD38 hematopoietic precursors derived from human embryonic stem cells exhibit an embryonic gene expression pattern

Shi-Jiang Lu, et al.
Source: BLOOD, 1 JUNE 2004  VOLUME 103, NUMBER 11

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Borate Glass Supports the In Vitro Osteogenic Differentiation of Human Mesenchymal Stem Cells

Nicholas W. Marion, et al.
Source: Mechanics of Advanced Materials and Structures, 12:1–8, 2005

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B and T Lymphocyte Attenuator Regulates B Cell Receptor Signaling by Targeting Syk and BLNK

Andrew C. Vendel, et al.
Source: J. Immunol. 2009;182;1509-1517

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