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Acute Myeloid Leukemia (AML)
Diseased Bone Marrow MNC

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Catalog # : AML-BM001F

BM is obtained from adult AML patients. BM-MNC are isolated by diluting the bone marrow with phosphate-buffered saline and using gradient separation techniques. After centrifugation, the MNC layer is collected. MNC can be processed further to isolate cell subpopulations. AML-MNC are available in the newly diagnosed and relapsed/refractory stages.
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Item #FormatDisease StageProduct nameSizePriceQuantity 
AML-BM001F CryopreservedTreatment Naive Mononuclear Cells (MNC) 10 million
Overview

Additional Information

BM is obtained from adult AML patients. BM-MNC are isolated by diluting the bone marrow with phosphate-buffered saline and using gradient separation techniques. After centrifugation, the MNC layer is collected. MNC can be processed further to isolate cell subpopulations. AML-MNC are available in the newly diagnosed and relapsed/refractory stages.

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Donor Criteria

Age+18 years old
Weight>= 110 lbs
Screened before donation
  • HIV (HIV 1 & 2 Ab)
  • HBV (Surface Antigen HbsAg)
  • HCV (HCVAb)
Donation FrequencyMinimum 10 weeks between donations
Donors with any of the following will be excluded from donating
  • Pregnancy
  • Active or serious acute or chronic infection requiring continued management
  • Serious pulmonary or cardiovascular disease or condition
Other Criteria
  • Other health conditions at discretion of donor's physician
  • Complete Blood Count lab test must meet protocol specs
  • Required to sign procedure-specific consent form

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CRYOPRESERVED CELL STORAGE
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Applications/Publications

Applications

  • Drug Screening
  • Toxicity or Immunogenicity Testing
  • Reagent validation

To Study

  • Everything

Related Bioservices

  • Th cell generation
  • T cell Proliferation analysis

Publications

Agonist antibody that induces human malignant cells to kill one another

Kyungmoo Yeaa , Hongkai Zhangb , Jia Xieb , Teresa M. Jonesb , Chih-Wei Linb , Walter Francesconic , Fulvia Bertond , Mohammad Fallahie , Karsten Sauerb,f, and Richard A. Lernerb
Source: Proceedings of the National Academy of Sciences of the United States of America, Contributed by Richard A. Lerner, September 25, 2015

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Rakicidin A effectively induces apoptosis in hypoxia adapted Bcr-Abl positive leukemic cells

Miki Takeuchi, et al.
Source: Cancer ScienceVolume 102, Issue 3, Article first published online: 19 DEC 2010

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Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia

S Hart, et al.
Source: Blood Cancer Journal (2011) 1, e44; doi:10.1038/bcj.2011.43 Published online 11 November 2011

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