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Bone Marrow MNC

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Catalog # : ABM024-0

  BM-MNC are isolated by diluting bone marrow with phosphatebuffered saline and using density gradient separation techniques. After centrifugation, the MNC layer is collected. MNC can be processed further to isolate various subpopulations.
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Catalog #FormatProduct nameSizePriceQuantity 
ABM007FCryopreserved Bone Marrow MNC5 million
$171.00
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ABM008FCryopreserved Bone Marrow MNC15 million
$318.00
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ABM009FCryopreserved Bone Marrow MNC25 million
$428.00
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ABM024Fresh Bone Marrow MNC25 million
$428.00
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$171.00
Overview

Additional Information

  BM-MNC are isolated by diluting bone marrow with phosphatebuffered saline and using density gradient separation techniques. After centrifugation, the MNC layer is collected. MNC can be processed further to isolate various subpopulations.

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Donor Criteria

Age18-65 years old
Weight>= 130 lbs
Screened before donation
  • HIV (HIV 1 & 2 Ab)
  • HBV (Surface Antigen HbsAg)
  • HCV (HCVAb)
Donation FrequencyMinimum 10 weeks between donations
Donors with any of the following will be excluded from donatingPregnancy
History of heart, lung, liver, or kidney disease
History of asthma
Blood and bleeding disorders including sickle cell disease
Neurologic disorders
Autoimmune disorders
Cancer
Diabetes
Other Criteria
  • Must be in general good health
  • Must have accessible hips
  • Complete Blood Count lab test must meet protocol specs
  • Required to sign procedure-specific consent form

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Applications/Publications

Applications

  • Drug Screening
  • Toxicity or Immunogenicity Testing
  • Reagent validation

To Study

  • Everything

Related Bioservices

  • Th cell generation
  • T cell Proliferation analysis

Publications

A novel antibody–drug conjugate targeting SAIL for the treatment of hematologic malignancies

SY Kim , J-W Theunissen , J Balibalos , S Liao-Chan , MC Babcock , T Wong , B Cairns , D Gonzalez , EH van der Horst , M Perez , Z Levashova , L Chinn , JA D‘Alessio , M Flory , A Bermudez , DY Jackson , E Ha , J Monteon , MF Bruhns , G Chen, and T-S Migone
Source: Citation: Blood Cancer Journal (2015) 5, e316; doi:10.1038/bcj.2015.39 Published online 29 May 2015

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Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes

Dong Hyun Kim, et al.
Source: Journal of Lipid Research Volume 54, 2013

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Increased heme-oxygenase 1 expression in mesenchymal stem cell-derived adipocytes decreases differentiation and lipid accumulation via upregulation of the canonical Wnt signaling cascade

Luca Vanella, et al.
Source: Vanella et al. Stem Cell Research & Therapy 2013, 4:28

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3, 39-Diindolylmethane Exhibits Antileukemic Activity In Vitro and In Vivo through a Akt-Dependent Process

Gao N,et al.
Source: PLoS ONE 7(2): e31783. doi:10.1371/journal.pone.0031783 February 21, 2012

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Rakicidin A effectively induces apoptosis in hypoxia adapted Bcr-Abl positive leukemic cells

Miki Takeuchi, et al.
Source: Cancer ScienceVolume 102, Issue 3, Article first published online: 19 DEC 2010

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The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML

V Novotny-Diermayr, et al.
Source: Blood Cancer Journal (2012) 2, e69; doi:10.1038/bcj.2012.14 Published online 4 May 2012

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Transfection of antisense core 2 b1,6-N-acetylglucosaminyltransferase-1 cDNA suppresses selectin ligand expression and tissue infiltration of B-cell precursor leukemia cells

J Kikuchi, et al.
Source: Leukemia (2005) 19, 1934–1940

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SHED repair critical-size calvarial defects in mice

BM Seo, et al.
Source: Oral Dis. 2008 July ; 14(5): 428–434.

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MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia

Shuangli Mi, et al.
Source: www.pnas.orgcgidoi10.1073pnas.0709313104

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Immunomodulatory properties of stem cells from human exfoliated deciduous teeth

Takayoshi Yamaza, et al.
Source: Yamaza et al. Stem Cell Research & Therapy 2010, 1:5

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HO-1 expression increases mesenchymal stem cell-derived osteoblasts but decreases adipocyte lineage

Luca Vanella, et al.
Source: BON-08643; No. of pages: 8; 4C: 7

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Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

Ravindra Majeti, et al.
Source: www.pnas.orgcgidoi10.1073pnas.0900089106

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Combined Abl Inhibitor Therapy forMinimizing Drug Resistance in ChronicMyeloid Leukemia: Src/Abl Inhibitors Are Compatiblewith Imatinib

Thomas O’Hare, et al.
Source: Cancer Therapy: Preclinical

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Apo A-1 mimetic peptide, L-4F prevents insulin resistance through increased HO-1 and pAMPK in obese mice

Stephen J. Peterson, et al.
Source: Journal of Lipid Research

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The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis

Claudia Scholl, et al.
Source: J. Clin. Invest. 117:1037–1048 (2007). doi:10.1172/JCI30182.

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Identification of a Hierarchy of Multipotent Hematopoietic Progenitors in Human Cord Blood

Ravindra Majeti, et al
Source: Cell Stem Cell. 2007 December 13; 1(6): 635–645

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SGX393 inhibits the CML mutant Bcr-AblT and preempts in vitro resistance whencombined with nilotinib or dasatinib

Thomas O’Hare, et al.
Source: www.pnas.org/cgi/doi/10.1073/pnas.0800587105

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Immunomodulatory properties of stem cells from human exfoliated deciduous teeth

Takayoshi Yamaza, et al.
Source: Yamaza et al. Stem Cell Research & Therapy 2010, 1:5

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