| Title | Description | Authors |  |
|---|---|---|---|
 Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures |
To identify accessible and permissive human cell types for efficient derivation of induced pluripotent stem cells (iPSCs), we investigated epigenetic and gene expression signatures of multiple postnatal cell types such as fibroblasts and blood cells. Source: Cell Research advance online publication 18 January 2011; doi: 10.1038/cr.2011.12 |
Linzhao Cheng, et al. |  |
| 15-deoxy-Δ12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis |
Platelet production is an intricate process that is poorly understood. Recently, we demonstrated that the natural PPARγ ligand, 15-deoxy-Δ12,14 prostaglandin J2 (15d-PGJ2), augments platelet production from megakaryocytes. Source: J Thromb Haemost. 2009 January ; 7(1): 182. doi:10.1111/j.1538-7836.2008.03191.x. |
Jamie J. O’Brien, et al. | |
| A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis |
Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting ∼1% of the adult population worldwide, with an estimated heritability of 60%. To identify genes involved in RA susceptibility, we investigated the association between putative functional single-nucleotide polymorphisms (SNPs) and RA among white individuals by use of a case-control study design; a second sample was tested for replication. Source: Am. J. Hum. Genet. 75:330–337, 2004 |
Ann B. Begovich, et al. | |
| A new approach for the large-scale generation of mature dendritic cells from adherent PBMC using roller bottle technology |
Human monocyte-derived DC (mDC) loaded with peptides, protein, tumor cell lysates, or tumor cell RNA, are being tested as vaccines against multiple human malignancies and viral infection with great promise. Source: Journal of Immune Based Therapies and Vaccines 2008, 6:1 |
Ryan E Campbell-Anson. et al. | |
| A Novel Dual-targeted Lentiviral Vector Leads to Specific Transduction of Prostate Cancer Bone Metastases In Vivo After Systemic Administration |
Targeted gene transduction to organs and tissues of interest is the ultimate goal of therapeutic gene delivery. Source: Molecular Therapy vol. 15 no. 11, 1973–1981 nov. 2007 |
Nonia Pariente, et al. | |
| A Predictive Model of Human Myelotoxicity Using Five Camptothecin Derivatives and the In vitro Colony-Forming Unit Granulocyte/Macrophage Assay |
Many promising anticancer drugs are limited by myelosuppression. It is difficult to evaluate human myelotoxicity before a Phase I study because of the susceptibility of humans and animals to hematotoxicity Source: Clinical Cancer Research Vol. 10, 6722–6731, October 1, 2004 |
Noriko Masubuchi, et al. | |
Sign-Up for Our eNewsletter
AllCells Resource Center
