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Mantle Cell Lymphoma (MCL)

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Background

Mantle Cell Lymphoma (MCL) is one of the rarer types of NHL. MCL is a disease of naïve pre-germinal center B cells, located in the “mantle zone” surrounding the normal germinal center follicles. A distinctive translocation at t(11;14)(q13;q32) causes upregulation of Bcl-1, development arrest, and unlimited proliferation of the mantle-zone B cells. This chromosomal translocation causes the over-expression of Bcl-1’s protein product, Cyclin-D1. In addition, these mantle-zone B cells express the CD5 marker. MCL is one of the few NHLs that can cross the blood-brain barrier.

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Mantle Cell Lymphoma (MCL)

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  Catalog # Format Name Size
cDNA-MCL-B008 cDNA MCL Bone Marrow CD19+/CD5+ B Cells (Relapsed/Refractory) 10 PCR rxns
RNA-MCL-B008C Comprehensive RNA MCL Bone Marrow CD19+/CD5+ B Cells (Relapsed/Refractory) 2 μg
MCL-B029F Frozen MCL Bone Marrow CD19+/CD5+ B Cells (Relapsed/Refractory) 20 million
MCL-B028F Frozen MCL Bone Marrow CD19+/CD5+ B Cells (Relapsed/Refractory) 10 million
MCL-B027F Frozen MCL Bone Marrow CD19+/CD5+ B Cells (Relapsed/Refractory) 5 million
cDNA-MCL-B007 cDNA MCL Bone Marrow CD19+/CD5+ B Cells (Untreated) 10 PCR rxns
RNA-MCL-B007C Comprehensive RNA MCL Bone Marrow CD19+/CD5+ B Cells (Untreated) 2 μg
MCL-B026F Frozen MCL Bone Marrow CD19+/CD5+ B Cells (Untreated) 20 million
MCL-B025F Frozen MCL Bone Marrow CD19+/CD5+ B Cells (Untreated) 10 million
MCL-B024F Frozen MCL Bone Marrow CD19+/CD5+ B Cells (Untreated) 5 million

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