Background | Dermal cells include different types of cells isolated from the skin. It can be largely separated into two groups by layers, epidermis and dermis. The epidermis contains the keratinocytes and melanocytes, and the dermis, which serves mainly as connective tissue, contains the fibroblasts. Keratinocytes make up the majority of the epidermis, and as it matures a single keratinocyte becomes enucleated, keratinized, and then becomes the barrier to the outside world. Melanocytes make melanins and are responsible for pigmentation. UV damage to the DNA sensitizes melanocytes and is one cause of melanogenesis, so is a very strong potential for melanoma. Fibroblasts are connective cells for other tissues, but have also been recently discovered for their potential susceptibility for genetic manipulation to produce pluripotent stem cells. |
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